Thangamani S, Younis W, Seleem MN (2015) Repurposing celecoxib as a topical antimicrobial
agent. Front. Microbiol 6:750. https://doi.org/10.3389/fmicb.2015.00750
Trezza A, Iovinelli D, Santucci A et al (2020) An integrated drug repurposing strategy for the rapid
identification of potential SARS-CoV-2 viral inhibitors. Sci. Rep. 10:13866. https://doi.org/10.
1038/s41598-020-70863-9
Tsubamoto H, Ueda T, Inoue K et al (2017) Repurposing itraconazole as an anticancer agent
(review). Oncol. Lett. 14:1240–1246
van de Klundert MAA, Zaaijer HL, Kootstra NA (2016) Identification of FDA-approved drugs that
target hepatitis B virus transcription. J. Viral Hepat. 23:191–201. https://doi.org/10.1111/jvh.
12479
Vanden Bossche H, Marichal P, Gorrens J et al (1988) Mode of action studies: basis for the search
of new antifungal drugs. Ann. N. Y. Acad. Sci. 544:191–207. https://doi.org/10.1111/j.
1749-6632.1988.tb40404.x
Warren TK, Jordan R, Lo MK et al (2016) Therapeutic efficacy of the small molecule GS-5734
against Ebola virus in rhesus monkeys. Nature 531:381–385. https://doi.org/10.1038/
nature17180
Wikan N, Smith DR (2016) Zika virus: history of a newly emerging arbovirus. Lancet Infect. Dis.
16:e119–e126
Xu K, Coté TR (2011) Database identifies FDA-approved drugs with potential to be repurposed for
treatment of orphan diseases. Brief. Bioinform. 12:341–345. https://doi.org/10.1093/bib/bbr006
Yan Z, Bryant KF, Gregory SM et al (2014) HIV integrase inhibitors block replication of Alpha-,
Beta-, and gammaherpesviruses. MBio 5:e01318-14. https://doi.org/10.1128/mBio.01318-14
Yeo WS, Arya R, Kim KK et al (2018) The FDA-approved anti-cancer drugs, streptozotocin and
floxuridine, reduce the virulence of Staphylococcus aureus. Sci. Rep. 8:2521. https://doi.org/10.
1038/s41598-018-20617-5
3
Drug Repurposing in Biomedical Research: Benefits and Challenges
35